Animal Models



NRL Drug Discovery Laboratories are fully equipped and capable of running various animal models with scientists of over 25 years of experience in pre-clinical biology and hands-on experience with conducting over 40 different animal models in-house. At present NRL-Drug Discovery Team is managing the following list of animal models:

DIABETES & OBESITY
  Glucose Clamp Studies
   in-vivo
  db/db Mouse Model
   Leptin receptor defective mouse model
  ob/ob Mouse Model
   Leptin gene knock-out ob/ob mouse model
  DIO Mouse Model
   Diet-Induced Obesity models in mice and rats
  FF-animal Models
   High-Fructose Fed animal models
  NOD-animal Models
   Type I diabetes model
  Zucker Model
   fa/fa rat and mouse models
  STZ-models
   Streptozotocin-induced beta cell knock-out model

RHEUMATOID ARTHRITIS & OSTEOARTHRITIS
  CIA-Mouse and Rat Models
   Collagen-Induced Arthritis model for Arthritis
  AIA-Mouse and Rat Models
   Adjuvant-Induced Arthritis model for Arthritis
  LPS-Mouse and Rat Models
   Lipopolysaccharide-Induced Inflammation model

INFLAMMATORY BOWEL DISEASE
  DSS-Mouse and Rat Models
   Dextran Sodium Sulfate Induced models for Colitis
  TNBS-Model
   Tri Benzene Sulphonic Acid models for Crohn's disease
  AAI-Model
   Acetic Acid Induced Inflammatory model
  OIC-Model
   Oxazolone Induced Colitis rat and mouse models

CANCER
  MCF-Xenograph Model
   Using human MCF-7 cell line for Breast Cancer
  PC-3 Xenograph Model
   Using human PC-3 cell line for Prostate Cancer
  DU-145 Xenograph Model
   Using DU-145 human cell line for Prostate Cancer
  HT-29 Xenograph Model
   Using HT-29 human cell line for Lung Cancer

MULTIPLE SCLEROSIS
  MBP-induced Mouse Model
   Myelin Basic Protein Induced model for MS
  Adoptive Transfer Model
   T-cell Adoptive Transfer model for MS
  PLP-induced Mouse Model
   Proteo Lipid Protein Induced model
  MOG-Murine Models
   Myelin Oligodendrocyte Glycoprotein Induced Models
  MSCH-Murine Models
   Mouse Spinal Chord Homogenate Induced Models
  HSCH-Human Model
   Human Spinal Chord Homogenate Induced Models

TOXICOLOGY STUDIES
NRL Drug Discovery Team has past experience of successfully conducting more than 20 drugs through different stages of Toxicology Studies. NRL is fully equipped to do in-house toxicology studies in rodents (Chronic and Acute studies). The company has extensive links to other credible organizations for conducting higher species toxicological evaluations.

CLINICAL TRIAL CAPABILITIES
Besides solid Pre-clinical Biology strength, Toxicology Studies, NRL-Drug Discovery Team is highly experienced in developing drugs from discovery up to Phase II clinical trials world-wide. This includes:

 
Designing of Clinical Trials for Phase I and Phase II
 
Liaison with US-FDA and European Drug Agencies
 
Clinical Trial Protocol Design and Approval by Regulatory Agencies
 
Building Highly Specialized Clinical Trial Teams
 
Manufacturing of Products with specifications for Clinical Trials Requirements
 
Filing and Approval of IND Applications
 
Licensing Opportunities with Clinical Data to Major Pharmaceutical Companies

In the past, our team has put together more than 10 drugs from discovery to Phase I and Phase II trials in last 25 years with all regulatory approvals in Europe and USA. Many such products were licensed to major pharmaceutical companies.